A Minimally Invasive Implant for Diagnosis and Treatment in Refractory Epilepsy

We are building an implantable device that can detect and predict epilepsy on-the-fly

There is a growing demand of chronic, wireless neurosenor interface with on-the-fly processing capabilities. Such neurosensor interface is designed with low power, low noise operation, thus meeting the urgent clinical needs of providing long-term, neurological health monitoring for patients who suffer from conditions such as epilepsy, Alzheimer's disease, and sleep apnea. In collaboration with Boston research groups, we have a wireless recorder designed and validated through bench-top experiments, animal experiments, and scalp EEG recordings.

What we have achieved:

  • An implantable chip capable of recording both regular EEG and high-frequency oscillations (up to 800Hz)
  • Recorder noise is 0.46µV for 0.1-100Hz and 0.98µV for 0.1-800Hz measured at 35uA/1.2V supply
  • Recording precision: 15 bit
  • A wireless power module that works at 1MHz and can deliver 1-10mW to the chip implant
  • Measured data rate can go beyond 1Mb/s
  • Wireless modules can work through skin and support 32-channel high frequency EEG data acquisition
  • Customized wireless transceiver board that can relay EEG data over 10 meters.

Advanced Microelectronics System for Neural Prosthesis and Organ Centric Disease Treatment

We developed various neural technologies to solve clinical problems.

Neurotechnologies that allow precise interactions with large-scale neural networks or peripheral nerves are ongoing pursuits of the neural engineering/neuroscience community and industry companies. High density recording is pushed by the BRAIN Initiative, which is to 10,000 times increase the number of neurons simultaneously recorded in the next 15 years. This is towards a better understanding of the brain. Neural interface that can selectively record and stimulate peripheral nerves are pushed by healthcare companies and major funding agencies, as an alternative mechanism that outperforms drugs in some disease treatment.

What we have achieved:

  • Developed technology that can realize simultaneous neural stimulation and recording
  • Designed an innovative integrated, low power peripheral neural amplifier that can possibly survive the large artifacts from the peripheral nerve recording environment and maintains extremely low noise to resolve axonal signals
  • Developed a set of neural signal processing algorithms implemented in integrated circuits, enabling "in-implant computing": signal processing inside the implant to reduce data rate
  • Neuronix: an innovative technology to interface with the axons in the nerve tap and a revolutionary interface for high density recording and stimulation.
  • A 1024-ch optical stimulator for high density neural stimulation.

Wearable Electronics and System in Healthcare and Lifestyle Applications

We investigate the applicaton of wearable devices in healthcare and lifestyle applications

Wearable electronics has a 30+ year's history, which share the vision of interweaving technology into the everyday life. Due to technology advancement and constant human needs for a better quality of life, wearable electronics market is booming especially in healthcare and life style applications. In 2014, there are 90 million wearables reaching customers including smart watch, wearable 3D motion trackers, sport/activity trackers, smart glasses, smart clothing, and wearable cameras. Along this direction, our group has developed multiple prototypes in collaboration with medical doctors and computer scientists, building tools for disease diagnosis and treatment. Some of our prototypes are in pilot clinical trials with positive feedbacks from both clinicians and patients

What we are working on:

  • A portable realtime infrared lids, iris and blink (PRILIB) monitoring system for diagnosis of ocular myasthenia gravis
  • A portable, light weighted pupil tracker to evaluate drowsiness and fatigue
  • A self-calibrated system to measure intraocular pressure for glaucoma
  • A smart belt for wirelessly monitoring patient ECG data and disease prevention
  • A smart insole for continuous foot pressure monitoring and motion tracking